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9th Mount Desert Island Stem Cell Symposium

A national research symposium hosted by MDIBL, The Jackson Laboratory, and Maine Medical Center Research Institute.

Date:  August 6–7, 2010
Location:   Mount Desert Island Biological Laboratory


The Mount Desert Island Stem Cell Symposium is a joint symposium of the Mount Desert Island Biological Laboratory, The Jackson Laboratory, and the Maine Medical Center Research Institute and is aimed at promoting the exchange of new ideas in stem cell research.

The 2010 symposium, Epigenetics and Regeneration, will emphasize current research findings and advances in the epigenetics of stem cell development, differentiation, and renewal, cancer, and the role of stem cells in tissue regeneration.

All interested scientists are welcome to preregister and attend. Travel funds are not available.


Faculty: $200

Corporate: $400

Students and Trainees: $50

The Jackson Laboratory Employees: meals only

Organizers, Invited Speakers, MDIBL Employees: no fee

Registration includes all meals.


Judi Medlin
Administrative Assistant
207-288-9880ext 100


Michael McKernan
Director, Education and Conferences

PROGRAM as of July 8, please check back for possible updates.

Friday, August 6
10:45 am Shuttle Van pics up attendees at The Regency Hotel, then to Best Western Acadia Inn, then to MDIBL. Cycles back as needed until approximately 12:45pm
11:00 am - 12:00 pm
Lobby, MDIBL Conference Center
12:00 pm - 1:00 pm   
Dining Hall
1:00 pm - 1:15 pm
Welcome and Introduction
Leonard Zon, M.D., and Jonathan Epstein, M.D., Symposium Co-chairs
Maren Auditorium, MDIBL Conference Center
Session 1: Epigenetic Regulation of Transcription and Expression
Maren Auditorium
1:15 pm

Andrew Xiao, Ph.D., Yale University
New functions of histone variant H2A.X in maintaining genome integrity 

1:40 pm

Richard Gregory, Ph.D., Children's Hospital, Boston
Regulation of microRNA biogenesis in embryonic stem cells and cancer

2:05 pm

John Rinn, Ph.D., Beth Israel Deaconess Medical Center
The role of large non-coding RNA in establishing epigenetic states of adult and embryonic cells and their misregulation in cancer

2:30 pm

Carla Kim, Ph.D., Children’s Hospital and Harvard Medical School
Stem cells in normal lung and lung cancer

2:55 pm
Break (30 min)
3:25 pm

Stuart Orkin, M.D., HHMI / Children's Hospital, Boston
Polycomb function in embryonic stem cells and cancer

3:50 pm

Alex Schier, Ph.D., Harvard University
The maternal-zygotic transition

4:15 pm

Leonard Zon, M.D., HHMI / The Children's Hospital
Transcriptional elongation and hematopoiesis

4:40 pm

Alex Meissner, Ph.D., The Broad Institute, Harvard University
Epigenetic reprogramming and cellular states

5:05 pm

Don Wojchowski, Ph.D., Maine Medical Center Research Institute
Novel regulators of progenitor cell survival discovered via global analyses of EPOR action

5:30 pm
Social Time
6:00 pm

Dining Hall

Shuttle Van will depart for hotels at 7:30pm and approximately 8:00pm

Saturday, August 7

7:15 & 7:45am

7:30-8:30 am

Shuttle van picks up attendees at The Regency Hotel, then Best Western Acadia Inn, then to MDIBL

Blueberry Pancake Breakfast
Dining Hall

Session 2: Cell Pluripotency and Reprogramming
Maren Auditorium
8:40 am

Jeanne Loring, Ph.D., The Scripps Research Institute
Systems biology focus on pluripotence

9:05 am

Susan Mango, Ph.D., Harvard University
Pluripotency and its loss during embryonic development

9:30 am

Konrad Hochedlinger, Ph.D., Massachusetts General Hospital
Factors influencing nuclear reprogramming

9:55 am

Richard Young, Ph.D., Whitehead Institute
Programming ES cell state

10:20 am
Break (25 min)
10:45 am

Kathrin Plath, Ph.D., UCLA
Reprogramming to pluripotency - insights into the mechanism

11:10 am

Bradley Cairns, Ph.D., HHMI / University of Utah School of Medicine
Germline chromatin: concepts shared in germ and ES cells

11:35 am

Elaine Fuchs, Ph.D., HHMI / The Rockefeller University
Wnt signaling and stem cell biology
Session 3: Regeneration
Maren Auditorium
12:00 pm

Dining Hall

1:15 pm

Fernando Camargo, Ph.D., Children's Hospital Boston
Hippo signaling pathway and the regulation of tissue/organ size and growth

1:40 pm

Tom Rando, M.D., Ph.D., Stanford University
Mechanisms of muscle stem cell ("satellite cell") activation in growth and regeneration of skeletal muscles

2:05 pm

Amy Wagers, Ph.D., Joslin Diabetes Center
Hematopoietic and skeletal muscle stem cells in mice

2:30 pm
Ben Stanger, M.D., Ph.D., University of Pennsylvania
Stem cells and progenitor cells in the vertebrate liver and pancreas
2:55 pm


3:20 pm

Daniel G. Anderson, Ph.D., Koch Institute for Integrative Cancer Research, MIT
Combinatorial Development of Biomaterials for Stem Cells

3:45 pm

Hal Broxmeyer, Ph.D., Indiana University School of Medicine
Influence of SIRT1, a member of the Sirtuin family of deacetylases, on maintenance and differentiation of mouse embryonic stem cells

4:10 pm

Nathan Lawson, Ph.D., UMass Medical School
Control of neovascularization by microRNAs

4:35 pm

Jayanta Roy-Chowdhury, M.D., Albert Einstein College of Medicine
Transplantation of stem cell-derived hepatocytes for treating inherited liver diseases

5:00 pm
Concluding Remarks
5:15 pm
Shuttle van deaprts MDIBL for hotels, will cycle back as needed

Dr. David Barnes, MDIBL
Dr. Edward Benz, Dana Farber Cancer Inst. and MDIBL
Dr. Paul Collodi, Purdue University
Dr. Jonathan Epstein, Univ. of Pennsylvania School of Medicine
Dr. John Macauley, The Jackson Laboratory
Dr. Rajesh Rao, Boston Eye and Ear Infirmary
Dr. Kevin Strange, MDIBL
Dr. Don Wojchowski, Maine Medical Center Research Institute
Dr. Kyuson Yun, The Jackson Laboratory
Dr. Leonard Zon, HHMI and Harvard School of Medicine

Travel to MDIBL

Parking: Early arrivers may park roadside, along Old Bar Harbor Road. Parking is also available in lots adjacent to the conference facilities. Directional signs will indicate where to park.


On campus: all onn campus housing has been filled.

Off campus: Rooms are available at the Best Western Acadia Park Inn for $159.00/night (AAA discount = $143.10/night). Please identify yourself as an attendee at the MDIBL Stem Cell Symposium. The Inn is within walking distance of the laboratory campus.

Other nearby accommodations can be found at the Bar Harbor Chamber of Commerce website

Speakers and Organizers will receive hotel reservation confirmations from MDIBL upon receipt of their travel itinerary.

Funds may become available to support registration, room, and board for students and trainees wishing to attend the symposium. Limited on campus dormitory housing is available on a first come first served basis; you must register to get on the list for housing consideration. Please contact Michael McKernan for more information.

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