The following investigators conducted research at MDIBL during the summer of 2002. Names marked by an asterisk (*) were New Investigator Awardees. Seasonal investigators are included at the bottom of this list. This list is also available for download.

*David Barnes, Ph.D.

Mount Desert Island Biological Laboratory
Derivation of continuous marine cell lines for model systems in toxicology and cell biology

Hermann Haller, M.D.

Web page
Hannover Medical School, Germany
Identification of regulatory genes in developing renal tissue of the spiny dogfish (Squalus acanthias) and in the little skate (Leucoraja erinacea)

George W. Kidder III, Ph.D.

Mount Desert Island Biological Laboratory and Illinois State University
Osmoregulation in euryhaline fish

Carolyn Mattingly, Ph.D.

Mount Desert Island Biological Laboratory
Curator, Bioinformatics Program

Denry Sato, Ph.D.

Mount Desert Island Biological Laboratory
1. Angiogenic growth factor signaling pathways
2. Structure and function of polypeptide growth factors in marine organisms

David W. Towle, Ph.D.

Mount Desert Island Biological Laboratory
1. Regulation of Na+K+-ATPase in crab gills
2. Osmoregulatory gene expression in euryhaline crabs
3. Functional genomic analysis of ecological limits in native and introduced crustaceans

SEASONAL RESEARCH AT MDIBL (May to November, 2002)

*Lisa Bain, Ph.D.

University of Texas at El Paso
Mechanisms of arsenic toxicity in mummichogs

*William Baldwin, Ph.D.

University of Texas at El Paso
Alterations in gene expression and transport due to putative PXR ligands in Pseudopleuronectes americanus (winter flounder)

Ned Ballatori, Ph.D.

University of Rochester School of Medicine
Membrane transport of drugs and xenobiotics

Edward J. Benz, Jr., M.D.

Dana-Farber Cancer Institute
1. Genes encoding Na, KATP’ase in Squalus acanthias
2. The protein 4.1 gene family in the dogfish shark

Nancy Berliner, M.D.

Yale University School of Medicine
Cloning & characterization of cDNAs encoding dogfish Na,K-ATPase and band 4.1

James L. Boyer, M.D.

Yale University School of Medicine
Molecular mechanisms of hepatic xenobiotic excretion

Peter M. Cala, Ph.D.

School of Medicine, University of California, Davis
Volume regulation by flounder RBCs: Implications for NHE1 structure/function relationships and control

Ian P. Callard, Ph.D.

Boston University
By-catch fishery of Squalus acanthias: Stress induced physiological response to catch and release fishing: impact on mortality and population recovery estimates

James B. Claiborne, Ph.D.

Georgia Southern University
Na+/H+ transport in fish gills: detection of the NHE antiporter

Lars Cleemann, Ph.D.

Georgetown University
Rapid TIRF imaging of subsarcolemmal Ca 2+ sparks in cardiomyocytes from shark and rat

Elizabeth L. Crockett, Ph.D.

Ohio University
Sterol limitation of zooplankton growth: Roles in nutrition and membrane biology

David C. Dawson, Ph.D.

School of Medicine, Oregon Health Sciences University
Physical basis of anion conduction by CFTR

Jonathan A. Dranoff, M.D.

Yale University School of Medicine
1. Nucleotide signaling and regulation of chloride secretion in killifish operculum
2. A novel nucleoside triphosphate diphosphohydrolase (NTPDase) from skate liver

Marlies Elger, Ph.D.

Medizinische Hochschule Hannover
Nephrogenesis in marine elasmobranchs (w/Dr. Hentschel)

*Franklin H. Epstein, M.D.

Harvard Medical School
Diverse pathways to chloride secretion by shark rectal gland (w/Drs. Hays and Silva)

David H. Evans, Ph.D.

University of Florida
Paracrine control of fish gill function

Susan K. Fellner, M.D.

University of North Carolina at Chapel Hill
Function of the calcium sensing receptor in rectal gland tubules and artery of Squalus acanthias

*Andreas W. Flemmer, M.D.

University Children’s Hospital Munich
Developmental expression of NKCC in Medaka

Biff Forbush III, Ph.D.

Yale University School of Medicine
Regulation of Na-K-Cl cotransport in the rectal gland of dogfish shark

John N. Forrest, Jr., M.D.

Yale University School of Medicine
1. Biology of membrane proteins regulating ion transport in the shark rectal gland
2. Signal transduction pathways regulating shark CFTR chloride channels
3. Toxicity of heavy metals in the shark rectal gland

Leonard R. Forte, Ph.D.

Missouri University
Guanylin peptides: Structures and cyclic GMP signaling mechanisms

*Gert Fricker, Ph.D.

Ruprecht-Karls-Universitat Heidelberg, Germany
Transport systems in blood brain barrier and choroid plexus

Raymond A. Frizzell, Ph.D.

School of Medicine, University of Pittsburgh
SNARE proteins in shark rectal gland secretion

Leon Goldstein, Ph.D.

Brown University
1. Regulation of osmolyte channels in skate RBC
2. Expression of osmolyte channels in Xenopus oocyes

*Criss Hartzell, Ph.D.

Emory University
Effect of heavy metals on cell cycle and ion transport

R. Patrick Hassett, Ph.D.

Ohio University
Sterol limitation of zooplankton growth: roles in nutrition and membrane biology (w/Crockett)

*Richard M. Hays, M.D.

Albert Einstein College of Medicine
Diverse pathways to chloride secretion by shark rectal gland (w/Drs. Epstein & Silva)

Raymond P. Henry, Ph.D.

Auburn University
Endocrine control of environmentally mediated induction of carbonic anhydrase in the gills of Carcinus maenas

Hartmut Hentschel, Ph.D.

Max-Planck-Institut fuer molekulare Physiologie,
Dortmund, Germany
Nephrogenesis in marine elasmobranchs (w/Dr. Elger)

*Shawn E. Holt, Ph.D.

Medical College of Virginia, Commonwealth University
Molecular cloning and characterization of telomerase components from marine animal species

*David Julian, Ph.D.

University of Florida
Hydrogen sulfide sensitivity: Free radicals, mitochondrial damage and cell death

Karl J. Karnaky, Ph.D.

Medical University of South Carolina
1. Role of guanylin in shark intestine
2. MRP2 transport processes in shark rectal gland and insect Malpighian tubule

*Grant Kelley, M.D.

SUNY Upstate Medical University
Toxicological effects of nickel on vasoactive intestinal peptide stimulated chloride secretion in the rectal gland of Squalus acanthias

Rolf K.H. Kinne, M.D., Ph.D.

Max-Planck-Institut fuer molekulare Physiologie, Dortmund, Germany
The effect of environmental pollutants on osmoregulatory mechanisms in gill and intestinal epithelium of the summer flounder, Paralychtis dendatus (w/Dr. Zeidel)

Thomas J. Koob, Ph.D.

Shriners Hospital for Children
1. Formation and properties of elasmobranch egg capsules
2. Cellular control of mutable echinoderm connective tissues
3. Biomechanics of hagfish notochord

*Seth W. Kullman, Ph.D.

Duke University, NSOE
Analysis of medaka fish CYP3A promoter regions and cloning of the orphan nuclear receptor PXR

Petra H. Lenz, Ph.D.

University of Hawaii at Manoa
Sensory reception and predator evasion in crustacean zooplankton

*Donald L. Lovett, Ph.D.

The College of New Jersey
Modulation of Na+,K+-ATPase in estuarine crabs during acute and acclimation responses to salinity change

*Carlos Marcelo Luquet, Ph.D.

University of Buenos Aires, Argentina
Molecular study of ion transport proteins in the gills of the hyper-hyporegulating crab Chasmagnatus granulatus

*John Mickle, Ph.D.

Johns Hopkins University School of Medicine
Molecular basis of CFTR-mediated salt secretion

David S. Miller, Ph.D.

NIH/NIEHS
The cellular and molecular biology of xenobiotic transport

Martin Morad, Ph.D.

Georgetown University Medical Center
The Na+-Ca2+ exchanger in the shark heart: Molecular determinants, cloning and
comparison with frog and mammal

*Thomas L. Pannabecker, Ph.D.

University of Arizona
Regulation of urea transport in the kidney of dogfish shark, Squalus acanthias

David Petzel, Ph.D.

Creighton University School of Medicine
1. Developmental expression of the Na/H exchanger in mosquito Malpighian tubules
2. Seasonal temperature effects on the expression of alpha isoforms of Na/K-ATPase from killifish gills

Robert L. Preston, Ph.D.

Illinois State University
Osmoregulation in euryhaline fish

J. Larry Renfro, Ph.D.

University of Connecticut
3. Regulation of sulphate transport by flounder renal epithelium and intestine
4. Flounder renal responses to physicochemical stresses

*John R. Riordan, Ph.D.

Mayo Clinic Scottsdale
CFTR and interacting proteins from shark rectal glands

*Patricio Silva, M.D.

Temple University
Diverse pathways to chloride secretion by shark rectal gland (w/Epstein and Hays)

*Céline Spanings-Pierrot, Ph.D.

Université Montpellier II, France
Neuroendocrine control of osmoregulation and gill ion transport

Bruce A. Stanton, Ph.D.

Dartmouth Medical School
Trafficking of CFTR in killifish operculum membrane: Response to seawater adaptation

James D. Stidham, Ph.D.

Presbyterian College
Electrophysiology of Fundulus epithelia (w/D. Evans)

*Andrea R. Tilden, Ph.D.

Colby College
Function, localization, and characterization of melatonin receptors in the crustacean nervous system

Alice R.A. Villalobos, Ph.D.

University of Rochester School of Medicine
Xenobiotic transport by choroid plexus

Mark L. Zeidel, M.D.

University of Pittsburgh
1. The effect of environmental pollutants on osmoregulatory mechanisms in gill and intestinal epithelium of the summer flounder, Paralychtis dendatus
2. Preliminary investigative studies to look for a putative aquaporin water channel in shark rectal gland